Can We Reset the Aging Brain?

The hypothalamus and hippocampus are central to aging—regulating hormones, memory, sleep, stress, and resilience. Chronic inflammation and neural degeneration in these regions accelerate cognitive and physical decline.

Dr. Sheldon Jordan, a leading neurologist, author, and prominent researcher is pioneering a regenerative neurology approach in SantaMonica that blends neuroimaging, biologic therapies, neuromodulation, and precision diagnostics to combat neural inflammation and repair pathways.

🔬 New Evidence on Hypothalamic Inflammation

A March 2023 study in PLOS Biology found that declining levels of Menin—a regulatory protein—in the ventromedial hypothalamus correlate with aging and cognitive deficits. Crucially, “restoring Menin expression … extended lifespan, improved learning and memory, and ameliorated aging biomarkers” (PLOS). Integrating this insight, Dr. Jordan’s protocols include strategies to modulate hypothalamic inflammation at a molecular level.

🧠 What's Up with Hippocampal Neurogenesis?

In June 2025, a study using genetically diverse mice (the DO strain) observed that although neurogenesis declines with age, “baseline levels of neurogenesis do not represent maximum neurogenic capacity”—highlighting how interventions like exercise or therapy could still stimulate growth (Wiley, Springer). This reinforces Dr. Jordan’s multimodal regimen that incorporates neuromodulation and biologic support to rekindle latent regenerative potential.

Taken together, these findings suggest:

• Restoring regulatory proteins like Menin could stall or reverse neuroinflammation.
• Even in aging brains, the hippocampus retains neurogenic capability—if properly supported.

Why This Matters

By targeting hypothalamic inflammation and stimulating hippocampal neurogenesis, his approach offers new hope for reversing age‑related cognitive decline, neurodegenerative conditions, and fatigue—through personalized brain reset protocols.

Curious if you’re a candidate for a brain reset protocol?
Schedule a consultation with GARM to learn about our protocol and explore how regenerative neurology may help reset your brain and slow aging.

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